Wat Phra Ram might have been built in 1369 A.D. by King Ramesuen on the site where the remains of his father, the King of U-thong, had been cremated. However, since King Ramesuen reigned only one year, he could not have completed the building. The Wat was either completed by King Boromaraja I or that king may have permitted others to complete it.

It is also possible that the temple was built during the second accession of King Ramesuen after the death of Boromaraja I. The temple was renovated several times, notably by King Boromatrailokanat and again in 1741 during the reign of King Boromakot.